When is a CEP revised?

A CEP is revised :

- as a result of notifications and/or minor revisions when there is an impact on its content (e.g. change in the address of the holder or manufacturing site, change to a test method appended to the certificate …).
- following a revision of the Ph. Eur. monograph when its content needs to be updated.
- after approval of a major change even if its content is not modified.

In cases where the CEP does not have to be revised, a letter is issued stating that the existing CEP remains valid after treatment of the request.