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Answer:I cannot achieve the system suitability or signal-to-noise criteria with the described chromatographic method. Can I make any adjustments?

Please consult general chapter 2.2.46, section “Adjustment of chromatographic conditions” for a list of acceptable modifications. However, multiple modifications are not recommended, and in any case, the system suitability criteria of the monograph and of general chapter 2.2.46 must be met.