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I cannot achieve the system suitability or signal-to-noise criteria with the described chromatographic method. Can I make any adjustments?

Please consult general chapter chapter 2.2.46, section “Adjustment of chromatographic conditions” for a list of acceptable modifications. However, multiple modifications are not recommended, and in any case, the system suitability criteria of the monograph and of general chapter chapter 2.2.46 must  must be met.